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Education

National Institute of Standards and Technology, Postdoctoral Fellow

Stanford University, Visiting Scholar, Bioengineering

2013-2016

  • Research Advisor: Matthew S. Munson
  • Visiting Scholar in the lab of Drew Endy

University of Michigan, Ph.D., Biomedical Engineering

2008-2013

Dissertation title: “Development of Magnetorotation as a Signal Transduction Method for Protein Detection.” [PDF]
  • Research Advisor: Raoul Kopelman
  • Committee Members: Xudong Fan, Ari Gafni, Alan Hunt, Robert Kennedy and Shuichi Takayama

University of California, Los Angeles, B.S., cum laude, Bioengineering

2004-2008

Honors and Awards

Nucleic Acids Research Breakthrough Article
NRC Postdoctoral Fellowship at NIST
U of M Rackham Predoctoral Fellowship
Finalist for U of M College of Engineering Towner Award for Outstanding PhD Research
DHS Graduate Research Fellowship

2017
2013
2012
2011
2008




Publications

A. Hecht, J. Filliben, S. Munro and M. Salit, "Reproducing small-scale cell growth and productivity measures." In preparation.

A. Hecht, J. Glasgow, P. Jaschke, L. Bawazer, M. Munson, J. Cochran, D. Endy, and M. Salit, "Measurements of translation initiation from all 64 codons in E. coli." Nucleic Acids Research, 45:3615-3626, 2017. [PDF] NAR Breakthrough article. Press release.

A. Hecht, D. Endy, M. Salit and M. Munson, "When wavelengths collide: bias in cell abundance measurements due to expressed fluorescent proteins." ACS Synthetic Biology, 5:1024-1027, 2016. [PDF]

A. Hecht, P. Commiskey, N. Shah, and R. Kopelman, "Bead Assembly Magnetorotation as a signal transduction method for protein detection." Biosensors and Bioelectronics, 48:26-32, 2013. [PDF]

R. Casaburi, J. Porszasz, A. Hecht, B. Tiep, et al, “Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy.” Journal of Chronic Obstructive Pulmonary Disease, 9:3-11, 2012. [PDF]

A. Hecht, A. Kumar, and R. Kopelman, “Label-acquired magnetorotation as a signal transduction method for protein detection: aptamer based detection of thrombin.” Analytical Chemistry, 83(18):7123-7128, 2011. [PDF]

A. Hecht, P. Kinnunen, B. McNaughton, and R. Kopelman, “Label-acquired magnetorotation for biosensing: An asynchronous rotation assay.” Journal of Magnetism and Magnetic Materials, 323:272-278, 2011. [PDF]

A. Hecht, G. Sommer, R. Durland, X. Yang, A. Singh, and A. Hatch, “Aptamers as affinity reagents in an integrated electrophoretic lab-on-a-chip platform.” Analytical Chemistry, 82(21):8813-8820, 2010. [PDF]

S. Ma, A. Hecht, J. Varga, M. Rambod, S. Morford, S. Goto, R. Casaburi and J. Porszasz, “Breath-by-breath quantification of progressive airflow limitation during exercise in COPD: A new method.” Respiratory Medicine, 104:389-396, 2010. [PDF]

A. Hecht, S. Ma, J. Porszasz, and R. Casaburi, “Methodology for describing daily activity of COPD patients using a triaxial accelerometer.” Journal of Chronic Obstructive Pulmonary Disease, 6:121-129, 2009. [PDF]



Oral Presentations

A. Hecht, "Non-canonical start codons and factors that affect growth and productivity of engineered cells.” NIST Bioforum, Gaithersburg, MD, Feburary 7, 2018.

A. Hecht, "Identifying opportunities for better measurements in iGEM (and beyond...)", iGEMeta Symposium, Boston, MA, July 7, 2017.

A. Hecht, M. Munson, D. Endy and M. Salit, “Context Dependence of Resources in Synthetic Biology Metrology: Mathematical Modeling, Implications for Measuring Construct Activity, and a Proposal for Context Characterization.” NIST Division 644 Seminar, Gaithersburg, MD, February 19, 2015.

M. Munson, A. Hecht, S. Rasaputra, S. Ghosh, L. Kennedy, M. Takahashi, D. Savage, and J. Lucks, “TXTL Best Practices,” Cold Spring Harbor Laboratory Synthetic Biology Course, Cold Spring Harbor, NY, August 10, 2014.

A. Hecht, M. Munson, D. Endy, and M. Salit, “Seeing the Invisible: Exploiting Crosstalk to Measure Genetic Constructs,” Control and Dynamical Systems (CDS) seminar series, California Institute of Technology, Pasadena, CA, July 18, 2014.

A. Hecht, P. Commiskey, N. Shah and R. Kopelman, “Label-Acquired Magnetorotation as a Protein Detection Platform.” Gordon Research Seminar: Bioanalytical Sensors, Salve Regina University, Newport, RI, June 16, 2012.

A. Hecht and R. Kopelman, “Label-Acquired Magnetorotation as a Novel Application of Magnetic Beads for Protein Detection.” Vaughan Symposium, University of Michigan, Ann Arbor, MI, July 28, 2011.

A. Hecht and R. Kopelman, “Label-Acquired Magnetorotation as a Novel Application of Magnetic Beads for Protein Detection.” Frontiers in BioMagnetic Particles, Clemson University, Charleston, SC, May 17, 2011.

A. Hecht, P. Kinnunen, B. McNaughton, and R. Kopelman. “Towards an asynchronous magnetic bead rotation method for immunological assays.” NanoTech 2010, Anaheim, CA, June 22, 2010.



Certifications

DataCamp Data Scientist with Python
Certified LabVIEW Associate Developer



Technical Skills

R / Python / MATLAB / LabVIEW / JavaScript / PHP / MySQL / HTML / CSS
Adobe Creative Suite
Microsoft Office Suite

Plasmid design, assembly, preparation and sequencing
Bacterial and yeast transformation and culture
PCR and gel electrophoresis
Fluorescence spectroscopy
In vitro transcription and translation
Aptamer and antibody conjugation
Assay design
Magnetic and nonmagnetic microparticles and nanoparticles